its the rubbing action and seals that will get you into trouble with the synthetic oil... mostly older engines.
I dont think your Harley has any "rubbing" action left in its design so your completly good to go! but for older things, with Flat Tappets in there camshaft or direct action followers like on my old Triumph the synthetic oil will destroy the engine in very very short time. Also if you have anything old that uses "rope", Asbestos, leather, cork, cardboard or non positive lip seals you will find big leaks in short time.
I can verify Dr. Frankensteins info about seals, etc. I switched my '87 FXR to synthetics at about 68,000 miles, had to replace many gaskets soon after. Kept with the synthetics, though, and when I sold it, at > 106,000 miles, the compression numbers were identical to what I'd recorded at 1,000 miles. My '05 FLHT has always had synthetics, no problems at all.
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